Table 6.
Adjusted Incidence of Suicide Attempts by Index Prescription: Zolpidem Versus Trazodone or Benzodiazepines or Antihistamines
| Agents (drug class) | Subjects (N) | Events (N) | Person-years | Suicide attempts per 100,000 person-years | Adjusted HR suicide attempt (95% CI) |
|---|---|---|---|---|---|
| Cox proportional hazard model 1 | |||||
| Trazodone | 76,215 | 57 | 74,742 | 76.3 | 1.61 (1.07–2.43) |
| Zolpidem | 76,215 | 38 | 74,625 | 50.9 | |
| Cox proportional hazard model 2 | |||||
| Benzodiazepines (temazepam, diazepam, or lorazepam) | 72,691 | 49 | 70,254 | 69.7 | 1.33 (0.85–2.08) |
| Zolpidem | 72,691 | 34 | 71,049 | 47.9 | |
| Cox proportional hazard model 3 | |||||
| Antihistamines (diphenhydramine, hydroxyzine) | 74,311 | 57 | 73,138 | 77.9 | 1.37 (0.90–2.07) |
| Zolpidem | 74,311 | 38 | 72,740 | 52.2 | |