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. 2019 Jul 23;28(4):1041–1049.e4. doi: 10.1016/j.celrep.2019.06.064

Figure 3.

Figure 3

LIPL-5/LIPF Limits Lifespan Extension in Response to Bacterial Deprivation

Lifespan analyses of C. elegans fed ad libitum (AL) or subjected to bacterial deprivation (BD).

(A) BD extended lifespan by 56% for wild-type animals (p < 0.0001) and 86% for lipl-5(ok3581) mutant animals (p < 0.0001). The mean lifespan of wild-type animals was similar to that of lipl-5(ok3581) mutant animals in similar conditions (p = 0.515). In BD, the lifespan of wild-type animals was 16% lower than that of lipl-5(ok3581) mutant animals (p < 0.001).

(B) BD extended lifespan by 72% for lipl-5(ok3581) mutant animals (p < 0.0001) and 50% for lipl-5(ok3581) mutant animals overexpressing lipl-5 behind its own promoter (p < 0.0001). The mean lifespan of lipl-5(ok3581) mutant animals was similar to that of lipl-5(ok3581) mutant animals overexpressing lipl-5 behind its own promoter in AL (p = 0.651). In BD, the lifespan of lipl-5(ok3581) mutant animals was 12% higher than that of lipl-5(ok3581) mutant animals overexpressing lipl-5 behind its own promoter (p < 0.001). Mean ± SD of n = at least 100 worms. Mantel-Cox log-rank test (see Table S2 for number of replicates).