Table 3.
Brain regions with significant differences in metabolic activity between 8 SNT+ SLE and 11 SNT− SLE subjects
| Brain region | Coordinates† | |||||||
| x | y | z | Zmax‡ | One-way ANOVA F, P value |
IHC (n=25) | SLE SNT+ (n=8) |
SLE SNT− (n=11) | |
| Metabolic Increases in SNT+ SLE compared with SNT− SLE | ||||||||
| Anterior putamen/caudate, left | −20 | −2 | 12 | 3.99 | 10.08, 0.0003 | 1.37 (0.07)§ | 1.48 (0.04)+++*** | 1.36 (0.06) |
| Anterior putamen, right | 22 | 2 | 12 | 3.62 | 6.02, 0.0051 | 1.43 (0.09) | 1.52 (0.07)++* | 1.40 (0.06) |
| Prefrontal cortex/BA 9, left | −34 | 24 | 28 | 3.30# | 9.32, 0.0005 | 1.60 (0.10) | 1.76 (0.13)+++** | 1.58 (0.08) |
| Prefrontal cortex/BA 9, right | 38 | 14 | 36 | 4.06 | 5.82, 0.0059 | 1.66 (0.14) | 1.73 (0.07)++ | 1.56 (0.06)* |
| Prefrontal cortex/BA 10, right | 14 | 42 | 16 | 3.92## | 13.74, <0.0001 | 1.55 (0.05) | 1.61 (0.05)+++* | 1.49 (0.06)** |
| Lateral frontal cortex/BA 8, left | −36 | 8 | 44 | 4.32# | 10.82, 0.0002 | 1.78 (0.09) | 1.89 (0.04)+++* | 1.70 (0.09) |
| Medial frontal cortex/BA 8, left | −10 | 30 | 52 | 4.03# | 13.27, <0.0001 | 1.68 (0.05) | 1.78 (0.05)+++*** | 1.66 (0.05) |
+P<0.05, ++p<0.01, +++p<0.001, post hoc Bonferroni tests of SLE SNT+ subjects versus SLE SNT− subjects.
*P<0.05, **p<0.01, ***p<0.001, post hoc Bonferroni tests of SLE SNT+ or SNT− subjects versus IHC group.
#P<0.05, ##p<0.01, corrected for cluster extent, SPM analysis of SLE SNT+ subjects versus SLE SNT− subjects.
†Montreal Neurological Institute (MNI) standard space56
‡Significant at p<0.001 (peak voxel, uncorrected), SPM analysis of SLE SNT+ subjects versus SLE SNT− subjects.
§Mean (SD) regional metabolism.
BA, Brodmann area;IHC, imaging healthy controls; SNT+/SNT−, SLE subjects completed/failed the spatial navigation task.