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. 2019 Jul 24;7:288. doi: 10.3389/fped.2019.00288

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Copyright © 2019 Wang, Ding, Chen, Xu, Qian, Qian, Cao, Zhou, Hou and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL6ST is a target gene of miR-223-3p. (A) Shows the IL6ST 3′UTR-containing reporter construct. Schematic representation of the miR-223-3p sequence, putative miR-223-3p targeting site in the 3′UTR of IL6ST, and the generated mutant IL6ST 3′UTR. (B) The western blot analysis shows that the cells transfected with miR-223 showed lower expression of IL6ST protein. (C) Luciferase reporter assay indicates the inhibitory effect that miR-223 has on the luciferase activity of IL6ST-3′UTR. (D) Correlation of the expression of IL6ST to that of miR-223-3p in KD samples using simple linear regression analysis. ***P < 0.001.