Figure 2.

Increased Inflammation and Inhibition of the Immunosuppressive Network in the TME by Virally Delivered CXCR4-A

(A–D) Accumulation of leukocytes (CD45⁺) (A), G-MDSCs (CD11b⁺Ly6G^hiLy6C^lo) (B), Tregs (CD4⁺CD25⁺Foxp3⁺) (C), and CD8⁺ T cells (D) in peritoneal washes of ID8-T ovarian tumor-bearing mice was analyzed by flow cytometry 8 days after treatment. (E) Memory subsets of CD8⁺ T cells were analyzed with mAbs specific for CD44 and CD62L antigens. Background staining was assessed using isotype control antibodies. Data are mean ± SD of three or four independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.