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. 2019 Apr 23;220(5):882–891. doi: 10.1093/infdis/jiz195

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Figure 4. — The region of difference 2 (RD2) element enhances the ability of serotype M28 group A Streptococcus (GAS) to adhere to human epithelial cells. The indicated strains were compared in tissue culture-based assays of adherence, using VK2/E6E7 (A) and A431 (B) human cell lines. Each experiment was performed on 4 occasions, with mean values (± standard errors of the mean) shown. For both data sets (A and B), P < .001 (via overall analysis of variance). Pair-wise strain comparisons were investigated using the Tukey multiple comparisons test, with P values shown. NS, not significant.