Figure 1.

Maternal cytomegalovirus (CMV)–specific immunoglobulin G (IgG) binding responses are similar between women whose infants did and those whose infants did not acquire CMV by 6 months of age. CMV-specific IgG binding responses of mothers whose infants were CMV infected (circles) or CMV uninfected (triangles) at 6 months of age. A and B, Whole-virion binding (A) and glycoprotein B (gB) binding (B) determined by enzyme-linked immunosorbent assay. C, Avidity of binding responses to whole virions (left) and gB (right). D, Total IgG binding (left) and IgG3 binding (right) to CMV antigens required for entry into epithelial cells. Dashed line indicates the limit of detection. The median of each data set is indicated with a line. AUC, area under the curve; ED₅₀, 50% effective dilution; MFI, median fluorescence intensity; PC, pentameric complex.