Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 24;12:182. doi: 10.3389/fnmol.2019.00182

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Dvoriantchikova, Seemungal and Ivanov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

DNA methylation dynamics during retinal progenitor cell (RPC) differentiation into retinal neurons revealed that high methylation levels of photoreceptor phenotypes in the genomic DNA of RPCs (which emerged early in embryogenesis) are inherited by non-photoreceptor retinal neurons, but the DNA methylation levels are sharply reduced in photoreceptor phenotypes. The DNA methylation of non-photoreceptor phenotypes is low in all studied cell types. The % of hypermethylated genes regulating RPC and retinal neuron phenotype development and function in genomes of (A) murine retinal progenitors [whole genome bisulfite sequencing (WGBS) data obtained from the current study and NCBI-Gene Expression Omnibus (GEO) WGBS data (GSE87062) for E14.5 retinas] (B) human retinal progenitors (NCBI-GEO GSE87061) (C) mature retinal neurons [retinal ganglion cell (RGC) WGBS data obtained from the current study and NCBI-GEO WGBS data (GSE84589) for horizontal cell (HC), starburst amacrine cell (SBAC), cones, and rods]. (D) The generated heat map reflects DNA methylation dynamics in promoters of photoreceptor genes during RPC differentiation into retinal neurons.