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. 2019 Jul 24;12:182. doi: 10.3389/fnmol.2019.00182

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Copyright © 2019 Dvoriantchikova, Seemungal and Ivanov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The methylation levels of genomic regions containing promoters of photoreceptor genes were sharply increased during the transition from the inner cell mass stage (ICM; E3.5) to the epiblast stage (E6.5). (A) Percentage of hypermethylated genes required for photoreceptor phenotypes in the genomic DNA of zygote, 8-cell blastocyst, ICM, and epiblast. (B) Heat maps show changes in DNA methylation levels in genomic regions containing promoters of photoreceptor genes during the early stages of embryogenesis.