Table 2.

Lipoprotein particle subfractions and GlycA in SLE and healthy controls as assessed by NMR

Lipoproteins	SLE (n=64)	Control (n=30)	P values
Baseline parameters
Total cholesterol, mg/dL	163.5 (148–191)	164.0 (145–202)	0.764
Triglycerides, mg/dL	86.5 (67–123)	77.0 (61–91)	0.131
HDL cholesterol, mg/dL	54.1± 16	66.9± 16	< 0.001
LDL cholesterol, mg/dL	99.0 (84–124)	85.5 (72–125)	0.359
VLDL triglycerides, mg/dL	59.9 (44– 87)	47.8 (36– 58)	0.031
GlycA	405.0 (365– 470)	357.5 (301– 411)	0.001
Particle counts
HDL particle count, umol/L	30.0± 5.9	35.0± 7.7	< 0.001
Small HDL particle count, umol/L	12.7±7.7	10.1±6.7	0.057
Medium HDL particle count, umol/L	8.1 (4– 12)	14.2 (9– 21)	< 0.001
Large HDL particle count, umol/L	6.9 (5– 10)	10.5 (9– 12)	0.001
LDL particle count, nmol/L	1094.0 (871– 1220)	843.5 (675– 1219)	0.029
Small LDL particle count, nmol/L	419.5 (211– 653)	271.0 (0– 389)	0.027
Large LDL particle count, nmol/L	419.5 (317–577)	445.0 (249–687)	0.805
IDL particle count, nmol/L	53.5 (25– 124)	130.5 (62– 190)	0.001
VLDL particle count, nmol/L	41.1 (29– 61)	33.3 (21– 47)	0.067
Small VLDL particle count, nmol/L	26.6 (18–38)	20.8 (14–34)	0.192
Medium VLDL particle count, nmol/L	13.5 (7– 25)	6.8 (2– 14)	0.007
Large medium VLDL particle count, nmol/L	14.7 (7– 27)	8.7 (3.7– 15.1)	0.017
Large VLDL particle count, nmol/L	2.3 (1.2–4.1)	1.8 (1.3–3.7)	0.961
Particle Size
HDL particle size, nm	9.6 (9.1– 9.9)	9.9 (9.5– 10.1)	0.013
LDL particle size, nm	21.0 (20.4–21.4)	21.1 (20.7–21.6)	0.295
VLDL particle size, nm	47.6 (43–51)	48.5 (45–54)	0.441

Student's t-test used unless otherwise noted (mean±SD).

Parameters reaching significance (p<0.05) highlighted in bold; after controlling for multiple comparisons only those with p <0.00009 remain significant.

*Mann-Whitney test used (median (IQR)).

GlycA, glycoprotein acetylation; HDL, high-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; NMR, nuclear MR; VLDL, very low-density lipoprotein.