Figure 4.

ST2L⁺ CD8^low T cells are transitional CCR7⁺ T cells. Distribution of naïve (CD45RA⁺RO⁻), transitional (Trans., CD45RA⁺RO⁺) and memory type (Mem., CD45RA⁻RO⁺) subpopulations of (A) CD8^low and (B) CD8^high T cells determined by flow cytometry. (C) Representative data for gating strategy of naïve, transitional, and memory type CD8^low and CD8^high. Percentage of ST2L expressing naïve, transitional, or memory type (D) CD8^low, and (E) CD8^high. (F) Representative histograms of ST2L expression of transitional CD8^low and naïve CD8^high. (G) Mean fluorescence intensity of ST2L⁺ CD8^low expressing CCR7, CD69, and KLRG1 and (H) representative flow cytometry data. Data are shown as mean ± SD of (A–F) n = 9 or (G,H) n = 5 of different donors with at least n = 3 independently performed experiments. **p < 0.01, ****p < 0.0001 using (A,B) Kruskal–Wallis test with Dunn's post-test or (D,E) Friedman test with Dunn's post-test.