Table II.

Prognostic values of ITGA subfamily gene expression in COAD of a TCGA cohort.

		OS
Gene	Patients (n=438)	No. of events	MST (days)	HR (95% CI)	Adjusted P-valuea
ITGA1
Low	329	77	3,042	1	0.303
High	109	21	2,134	0.775 (0.477–1.259)
ITGA2
Low	329	78	2,532	1	0.176
High	109	20	NA	0.711 (0.434–1.165)
ITGA2B
Low	329	74	2,475	1	0.792
High	109	24	NA	1.064 (0.670–1.691)
ITGA3
Low	329	70	2,532	1	0.898
High	109	28	2,047	0.971 (0.620–1.521)
ITGA4
Low	329	73	2,821	1	0.434
High	109	25	1,661	1.203 (0.757–1.912)
ITGA5
Low	329	73	2,821	1	0.016
High	109	25	2,047	1.681 (1.100–2.570)
ITGA6
Low	329	77	2,532	1	0.284
High	109	21	NA	0.767 (0.471–1.246)
ITGA7
Low	329	73	2,532	1	0.763
High	109	25	3,042	0.932 (0.59–1.472)
ITGA8
Low	329	80	2,475	1	0.206
High	109	18	NA	0.718 (0.430–1.199)
ITGA9
Low	329	62	2,821	1	0.165
High	109	36	2,047	1.340 (0.887–2.024)
ITGA10
Low	329	69	2,821	1	0.069
High	109	29	2,047	1.506 (0.969–2.343)
ITGA11
Low	329	70	2,821	1	0.641
High	109	28	1,910	1.111 (0.713–1.731)
ITGAD
Low	329	73	2,475	1	0.801
High	109	25	3,042	1.060 (0.672–1.672)
ITGAE
Low	329	80	2,475	1	0.438
High	109	18	NA	0.815(0.486–1.366)
ITGAL
Low	329	72	2,532	1	0.173
High	109	26	2,134	1.370 (0.871–2.156)
ITGAM
Low	329	72	2,821	1	0.382
High	109	26	2,134	1.222 (0.779–1.917)
ITGAV
Low	329	81	2,532	1	0.327
High	109	17	2,047	0.768(0.452–1.303)
ITGAX
Low	329	76	2,532	1	0.665
High	109	22	3,042	1.111(0.689–1.793)

^aAdjusted P-value, adjustment for TNM stage. COAD, colon adenocarcinoma; ITGA, integrin α; OS, overall survival; MST, median survival time; 95% CI, 95% confidence interval; HR, hazards ratio; NA, not available.