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. 2019 Jul 15;42(3):1047–1056. doi: 10.3892/or.2019.7234

Figure 1.

Figure 1.

Low miR-198 tumor abundance is associated with high Gleason score and reduces the aggressive phenotype in vitro. (A) miR-198 abundance in prostate tumor samples from a CPC-GENE dataset with Gleason Score (GS) ≤7 (n=149) or GS >7 (n=13). The boxplot represents the median with IQR, and outliers are included in the analysis (two-sided Wilcoxon test, P=0.02) (B) Proliferation assays after transfection with control or miR-198 mimic in DU145 and LNCaP cells. Total viable cells were counted after 4 days (DU145) or 5 days (LNCaP), and normalized to the number of cells in the control mimic condition. (C) Cell cycle profile from flow cytometry of LNCaP cells 48 h after transfection with control or miR-198 mimic. (D) Soft agar assay results from DU145 and LNCaP cells with control/miR-198 mimic transfection. Number of colonies counted after 30 days incubation. Representative images from soft agar experiments. The mean ± SEM and statistical significance are denoted (*P<0.05, **P<0.01 and ***P<0.001).