Table 2.
Summary of treatment regimens, biochemical remission rates (normal ALT and IgG) and number of patients cirrhotic at diagnosis according to treatment regimen (n = 1198, excluding liver transplant patients)a
| Simplified drug regimen | Number of patients (%) | Number in biochemical remission (%) | Number cirrhotic at diagnosis (%) |
|---|---|---|---|
| Azathioprine/MP alone | 392 (33) | 252/362 (70) | 82/385 (21) |
| Azathioprine/MP + prednisolone | 316 (26) | 175/299 (59) | 78/309 (25) |
| Prednisolone alone | 103 (9) | 43/85 (51) | 28/98 (29) |
| Budesonide alone | 19 (2) | 5/19 (26) | 2/19 (11) |
| No immunosuppression | 85 (7) | 51/79 (65) | 15/84 (18) |
| MMF/MA alone | 58 (5) | 35/54 (65) | 11/57 (19) |
| MMF/MA + prednisolone | 112 (9) | 53/107 (50) | 34/112 (30) |
| CNI‐containing regimenb | 56 (5) | 16/54 (29) | 19/56 (34) |
| Triple immunosuppression | 28 (2) | 5/27 (19) | 9/27 (33) |
| Other immunosuppression regimen | 53 (4) | 24/51 (47) | 3/53 (6) |
ALT: alanine aminotransferase; IgG: immunoglobulin G; MP: mercaptopurine; MMF: mycophenolate mofetil; MA: myphenolic acid; CNI: calcineurin inhibitor.
a
All available data presented but some missing data resulting in denominators for the calculation of biochemical remission and numbers cirrhotic at diagnosis being smaller than the total number of included patients.
b
Some patients on a CNI‐containing regimen were receiving triple immunosuppression so appear in both groups resulting in n > 1198.