Table I.
Clinical-pathologic parameters in patients with DCIS (n=94) and DCISM (n=53).
| Clinical-pathologic parameters | DCIS, n=94 (%) | DCISM, n=53 (%) | P-value |
|---|---|---|---|
| Age (years) | 48±11a | 46±8a | 0.267 |
| Menopausal status | 0.728 | ||
| Premenopausal | 63 (67.0) | 37(69.8) | |
| Postmenopausal | 31 (33.0) | 16(30.2) | |
| Clinical presentation | 0.015 | ||
| Mass | 58 (61.7) | 38 (71.7) | |
| Nipple discharge | 16 (17.0) | 13(24.5) | |
| Asymptomatic | 20 (21.3) | 2 (3.8) | |
| Family history of breast cancer | 0.509 | ||
| Yes | 2 (2.1) | 3 (5.7) | |
| No | 92 (97.9) | 50 (94.3) | |
| Personal history of breast cancer | 0.480 | ||
| Yes | 3 (3.2) | 0 (0.0) | |
| No | 91 (96.8) | 53 (100.0) | |
| Maximum diameter (cm)a | 2.1±1.5a | 3.4±1.5a | <0.001 |
| Nuclear grade | <0.001 | ||
| Low or intermediate | 68 (72.3) | 11 (20.8) | |
| High | 26 (27.7) | 42 (79.2) | |
| Comedo-type necrosis | <0.001 | ||
| Yes | 3 (3.2) | 17 (32.1) | |
| No | 91 (96.8) | 36 (67.9) | |
| Estrogen receptor | <0.001 | ||
| Positive | 86 (91.5) | 31 (58.5) | |
| Negative | 8 (8.5) | 22 (41.5) | |
| Progesterone receptor | <0.001 | ||
| Positive | 76 (80.9) | 16 (30.2) | |
| Negative | 18 (19.1) | 37 (69.8) | |
| HER2 status | 0.001 | ||
| 0, 1+ | 46 (48.9) | 11 (20.8) | |
| 3+ | 16 (17.1) | 21 (39.6) | |
| 2+ | 32 (34.0) | 21 (39.6) | |
| Ki-67 index (%) | 0.006 | ||
| >20 | 28 (29.8) | 28 (52.8) | |
| ≤20 | 66 (70.2) | 25 (47.2) |
a
Data are presented as the mean ± SD. DCIS, ductal carcinoma in situ; DCISM, ductal carcinoma in situ with microinvasion; HER2, human epidermal growth factor receptor 2.