Table 6.
Overview of the published literature on the use of 18Fluorocholine positron emission tomography in patients with hyperparathyroidism.
| Author (date) | Patients (n) | PHPT type | Sex | Age, years (range) | Preop. calcium | Preop. PTH | Dose used | Timing | Success |
| Quak (2013)7 | 1 | Primary | 1M | 71 | 2.84 | 91.8 pg/l (< 80) | – | – | 1/1 |
| Orevi (2014)16 | 40 | Primary/tertiary | – | 55 (21–72) | 2.8 | 15.9 pmol/l | 370 MBq | 11 minutes | 24/27 |
| Lezaic (2014)13 | 24 | Primary | 4M, 20F | (42–77) | Med : 2.7 | Med:83.5 pg/mL | 100 MBq | 60 minutes | 36/40 |
| Van Raalte (2015)14 | 2 | Primary | – | 69, 66 | 2.73, 2.96 | 32.3 pmol/l, 19.0 pmol/l | 175 MBq | 40 minutes | 2/2 |
| Michaud (2015)15 | 17 | Primary/secondary/lithium | 5M, 12F | 52 (25–75) | X | 280 pg/ml (range 61–1946 pg/ml) | 3 MBq/kg | 10 minutes | 16/17 |
| Rep (2015)18 | 43 | Primary | 8M, 35F | 59.6 (11) | 2.8 | 311.5 ng/l | 100 MBq | 5 minutes, 1 hour, 2 hours | 40/43 |
| Kluijfhout (2015)11 | 5 | Primary | – | – | – | – | 2 MBq/kg | – | 4/5 |
| Kluijfhout (2016)10 | 44 | Primary/tertiary | 11M, 33F | 58.9 (31–80) | 1.08 | 2.11 | 2 MBq/kg | – | 33/35 |
| Behera (2016)9 | 2 | Primary | 2M | 38, 58 | – | – | – | – | 2/2 |
| Hocevar (2017)19 | 151 | Primary | 30M, 121F | 61.1 (13–82) | – | – | 100 MBq | 5 minutes, 1 hour | 122/126 |
| Quak (2018)17 | 25 | Primary | 10M, 15F | 58.9 (14.2) | 2.76 | 94.8 ng/l | 1,5 MBq/kg | 60 minutes | 19/25 |
PHPT, Primary hyperparathyroidism; PTH,: Parathyroid hormone, Adjusted calcium normal values (2.2-2.6 mmol/L), PTH normal values (1.8-6.8 pmol/l, 10-65 ng/l).