Figure 4.

PrP silencing and blocking Notch1 activation collaborates to suppress cancer cell growth in xenografts. A and B: BxPC-3 (A) and Panc-1 (B) control or PrP-KD cells were injected ipsilaterally on the back of nude mice. Paired animals received either PBS (control or PrP-KD) or DBZ (control + DBZ or PrP-KD + DBZ) for 3 consecutive days every 7-day cycle. Tumor volumes were measured weekly and at the end of experiments (6 weeks for BxPC-3 and 7 weeks for Panc-1). B: Shown are Panc-1 tumor sizes at week 7 (inset). t-test was performed (A and B). Data are expressed as tumor volume ± SD. n = 5 in each group. ^∗P < 0.05, ^∗∗P < 0.01. Ctrl, control; DBZ, dibenzazepine; KD, knock down; PBS, phosphate-buffered saline; PrP, prion protein.