Table 2.
Pairwise correlation between DAS28CRP, Krenn score, EULAR-OMERACT US scores and RAMRIS MRI scores of the RCJ of the wrist. Baseline correlations (below the diagonal) and 6-month data (above the diagonal)
| ERA | DAS28-CRP | Krenn score | Larsen score* | EO US combined | EO US Doppler | EO US GS | MRI synovitis | MRI erosion | MRI bone oedema |
| DAS28CRP | – | r=0.34 p=0.09 | r=0.04 p=0.82 | r=−0.14 p=0.57 |
r=−0.22 p=0.31 |
r=−0.15 p=0.51 |
r=0.10 p=0.72 |
r=−0.21 p=0.34 |
r=−0.24 p=0.33 |
| Krenn score | r=0.32 p=0.09 | – | r=0.00 p=1.00 |
r=0.18 p=0.38 | r=0.10 p=0.72 |
r=0.18 p=0.44 |
r=0.14 p=0.65 | r=−0.10 p=0.80 |
r=−0.48 p=0.24 |
| Larsen X-ray score* | r=0.09 p=0.68 | r=0.13 p=0.19 | – | r=0.03 p=0.90 |
r=−0.40 p= 0.03 |
r=0.03 p=0.90 |
r=0.27 p=0.14 | r=−0.19 p=0.09 |
r=−0.10 p=0.34 |
| EO US combined score | r=0.12 p=0.34 |
r=0.77 p< 0.001 | r=0.23 p=0.21 |
– |
r=
0.62
p= 0.001 |
r=1† p< 0.001 | r=0.17 p=0.11 |
r=
0.26
p= 0.01 |
r=
0.14
p= 0.02 |
| EO US Doppler score | r=0.08 p=0.66 |
r=
0.72
p< 0.001 |
r=0.14 p=0.17 | r=0.88 p< 0.001 | – |
r=
0.62
p< 0.001 |
r=
0.41
p= 0.02 |
r=
0.40
p< 0.001 |
r=
0.32
p< 0.001 |
| EO US GS score | r=0.19 p=0.24 |
r=
0.86
p< 0.001 |
r=0.29 p=0.08 |
r=0.92 p< 0.001 |
r=
0.77
p< 0.001 |
– | r=0.27 p=0.14 |
r=
0.26
p= 0.01 |
r=
0.14
p= 0.02 |
| MRI synovitis score | r=0.23 p=0.25 | r=0.85 p< 0.001 |
r=
0.37
p= 0.002 |
r=
0.73
p< 0.001 |
r=
0.68
p< 0.001 |
r=
0.83
p< 0.001 |
– |
r=
0.44
p= 0.03 |
r=0.09 p=0.11 |
| MRI erosion score | r=0.10 p=0.36 | r=0.00 p=1.00 | r=−0.18 p=0.09 | r=−0.03 p=0.91 | r=0.11 p=0.60 | r=0.03 p=0.91 |
r=0.08 p=0.60 |
– | r=0.55 p=0.26 |
| MRI bone oedema score | r=0.09 p=0.36 | r=0.13 p=0.43 | r=−0.15 p=0.17 | r=0.20 p=0.25 | r=0.27 p=0.07 | r=0.25 p=0.06 | r=0.12 p=0.49 |
r=
0.79
p= 0.03 |
– |
| LRA | |||||||||
| DAS28CRP | – | r=0.45 p= 0.04 | r=0.32 p=0.16 |
r=
0.57
p= 0.01 |
r=
0.62
p= 0.002 |
r=
0.50
p= 0.003 |
NA | NA | NA |
| Krenn score | r=−0.03 p=0.87 | – | r=0.20 p=0.53 |
r=
0.81
p< 0.001 |
r=
0.63
p= 0.002 |
r=
0.77
p< 0.001 |
NA | NA | NA |
| Larsen X-ray score* | r=0.06 p=0.75 | r=0.42 p=0.08 | – | r=0.37 p=0.17 |
r=
0.56
p= 0.01 |
r=0.24 p=0.35 | NA | NA | NA |
| EO US combined score | r=0.36 p=0.14 | r=0.83 p< 0.001 |
r=
0.44
p= 0.02 |
– |
r=
0.72
p< 0.001 |
r=
0.96
p< 0.001 |
NA | NA | NA |
| EO US Doppler score | r=0.35 p=0.09 |
r=
0.75
p< 0.001 |
r=0.38 p=0.06 |
r=
0.82
p< 0.001 |
– |
r=
0.65
p< 0.001 |
NA | NA | NA |
| EO US GS score | r=0.35 p=0.13 |
r=
0.79
p< 0.001 |
r=0.16 p=0.51 |
r=
0.93
p< 0.001 |
r=
0.73
p< 0.001 |
– | NA | NA | NA |
| RAMRRIS synovitis score | r=0.42 p= 0.04 | r=0.61 p= 0.002 |
r=
0.48
p= 0.003 |
r=
0.72
p= 0.002 |
r=
0.74
p< 0.001 |
r=
0.58
p= 0.004 |
– | NA | NA |
| MRI erosion score | r=0.42 p=0.10 |
r=0.27 p=0.13 |
r=
0.59
p= 0.004 |
r=
0.51
p= 0.008 |
r=
0.53
p= 0.008 |
r=0.31 p=0.13 |
r=
0.55
p= 0.004 |
– | NA |
| MRI bone oedema score | r=0.27 p=0.37 |
r=0.13 p=0.32 |
r=
0.37
p= 0.03 |
r=
0.32
p= 0.01 |
r=
0.29
p= 0.01 |
r=0.27 p=0.06 |
r=0.37 p=0.07 |
r=
0.75
p= 0.01 |
– |
Comparisonby unadjusted linear regression with robust cluster estimation. NA: Not available, as the LRA did not have 6-month MRI. Significant correlations in bold.
*Total Larsen wrist score (all quadrants).
†The combined US scores are the same as the GS scores in the ERA 6-month visit group.
DAS28CRP, disease activity score in 28 joints with CRP level included; EO, EULAR-OMERACT; ERA, early rheumatoid arthritis; GS, grey scale; LRA, long-standing rheumatoid arthritis; RCJ, radiocarpal joint; US, ultrasound.