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. 2019 Jul 24;10:1752. doi: 10.3389/fimmu.2019.01752

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Copyright © 2019 Quinlan, Merino-Serrais, Di Grande, Dussmann, Prehn, Ní Chonghaile, Henshall and Jimenez-Mateos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypoxia induces seizures at P7 results in neuronal morphology alterations later in life. (A) Field view of hippocampi showing Lucifer yellow injected CA1 neurons (green) and nuclei (Red). (B) Higher magnification CA1 injected neuron from the control (left) and hypoxia (right) group. (C) Representative images of the basal dendritic tree from the control and hypoxia group. (D) Number of basal dendrites per soma (F: 3.354, t: 6.854), (E) total dendritic length (F: 2.322, t: 2.435), (F) length of an individual dendrite (F: 1.588, t: 2.818) and (G) number of branches in control and hypoxia group (F: 16.90, t: 4.135). Scale bar: (A) 500 μm and (B,C) 10 μm. (n = 17–20 neurons per group from 4 mice per condition). (*P < 0.05, **p < 0.01, ***p < 0.001).