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. 2019 Jul 24;10:1752. doi: 10.3389/fimmu.2019.01752

Figure 4.

Figure 4

Targeting inflammation modulates hypoxia-induced seizures in P7 mice (A) Representative EEG traces from mice pre-treated with vehicle or CND and exposed to hypoxia-induced seizures. (B–D) Quantification of EEG files show that mice treated with CND have a delayed onset to first seizures (B; F: 8.309, t: 3.386), further, these mice also have significantly reduced in total power (C; F: 5.486, t: 3.361) and seizure burden (D; F: 1.913, t: 3.230) (n = 5–7 per group. *p < 0.05, **p < 0.01). (E) CND-treated pups experienced also significantly shorter seizures (n = 5–7 per group. *p < 0.05. F: 2.466, t: 2.411). Mice exposed to CND have a reduction in IL1β (F; F: 778.6, t: 2.085), without affecting TNFα (G) (n = 5 per group. *p < 0.05).