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. 2019 Jul 24;10:1752. doi: 10.3389/fimmu.2019.01752

Figure 6.

Figure 6

CND normalizes the anxiety-like behaviors and memory impairment caused by hypoxia-induced seizures. (A–D) Motor and anxiety-related behavior in mice exposed to hypoxia and/or receiving CND at P7. (A) Representative behavior tracking of controls, CND, hypoxia and hypoxia-CND in the open field test. (B–D) Distance move, time spent in periphery and freezing time in the 10 min of recording (n = 11–13). (E,F) Representative view above the light-dark box shows the location of the mouse at the start of the test and the tracks and graph quantifying the latency to the first transition to the dark zone [n = 11–13, *p < 0.05, **p < 0.01 compared to control, CND and Hyp-CND group. F: 4.036, t: 3.127 (vs. control), t: 1.723 (vs. CND), t: 2.918 (vs. Hyp-CND)]. (G,H) Schematic and quantification of the novel-object position test [n = 11–13, *p < 0.05, **p < 0.01 compared to control, CND and Hyp-CND group. F: 7.515, t: 3.126 (vs. control), t: 3.392 (vs. CND), t: 4.565 (vs. Hyp-CND)].