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. 2019 Jul 26;11:7111–7122. doi: 10.2147/CMAR.S201341

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© 2019 Yang et al.

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Silibinin sensitize the antitumor activity of cisplatin and/or taxol on A2780/cisplatin-resistant (A2780/DDP) human ovarian carcinoma cells. (A) The IC₅₀ values of cisplatin, silibinin plus cisplatin, taxol and silibinin plus taxol on A2780/DDP cells, the values were determined by MTT assay after cisplatin, or silibinin plus cisplatin, or taxol, or silibinin plus taxol treated for 48 h. (B) The A2780/DDP cells were treated with silibinin (50 μM), cisplatin (115 μM), taxol (50 μM) and silibinin (50 μM) plus cisplatin (115 μM) and/or taxol (50 μM) for 48 h, and then the cell viability was determined by MTT assay. The results were shown as the percentage of cell viability in control group. The Bar chart of all data represents mean ± SD of three independent experiments, *p<0.05, **p<0.01 and ***p<0.001 vs control group.