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. 2019 Jul 26;11:7111–7122. doi: 10.2147/CMAR.S201341

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© 2019 Yang et al.

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The combination of silibinin and cisplatin or taxol decreases cell-matrix adhesion and inhibits A2780/DDP cells proliferation. (A) The effect of silibinin, cisplatin and/or taxol on cells adhesion to the extracellular matrix. Cells were treated with silibinin (50 μM), cisplatin (115 μM), taxol (50 μM) and silibinin (50 μM) plus cisplatin (115 μM) and/or taxol (50 μM) for 48 h and subjected to cell adhesion assay in which the cells attaching to the extracellular matrix were stained and counted. (B) Proliferation curve of A2780/DDP cells in the presence of silibinin (50 μM), cisplatin (58 μM), taxol (25 μM) and silibinin (50 μM) plus cisplatin (58 μM) and/or taxol (25 μM). The Bar chart of all data represents mean ± SD of three independent experiments, *p<0.05, **p<0.01 and ***p<0.001 vs cisplatin or taxol treated alone group.