Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 26;11:7111–7122. doi: 10.2147/CMAR.S201341

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Yang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Silibinin protects hepatocyte cell DNA against damage. (A) IF assay for evaluating the DNA damage. LO2 cells were treated with 0.01% DMSO (Control), silibinin (50 μM), cisplatin (24 μM), taxol (4 μM) and silibinin (50 μM) plus cisplatin (24 μM) and/or taxol (4 μM) for 48 h. DAPI and 53BP1 was the nucleus dye (blue) and DNA damage marker (green), respectively. (B) Quantification of (A). The results show the percentage of 53BP1 foci per cell among 200 untreated and treated cells, respectively. Values are the average ± SD of three independent experiments. ***p< 0.001.