Fig. 6.

Efficacy of combination therapy is similarly observed in a subcutaneous lung cancer model. Combination therapy was tested in the murine LLC lung cancer model. Tumors were allowed to grow to an average of 100mm³ per group before initiation of treatment (red arrow). Average fold change of tumor volume of mice treated with combination therapy (Combo), chemotherapy (Chemo) alone, or immunotherapy (IT) alone as well as vehicle only (Vehicle). The number of mice per group (n) are listed. All experiments were performed with biological replicates twice. Statistics were calculated using two-way ANOVA and the Log-rank (Mantel-Cox) test. * p ≤ 0.05, *** p ≤ 0.001, **** p ≤ 0.0001