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. 2019 Jul 24;10:938. doi: 10.3389/fphys.2019.00938

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Copyright © 2019 Gál, Dolenšek, Stožer, Pohorec, Ébert and Venglovecz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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[Ca²⁺]_i response in ductal cells after stimulation with 1 mM CDCA. (A) Confocal fluorescence image of a ductal structure and surrounding acinar tissue with selected regions of interest (ROI) denoting nuclei of individual PDECs. (B) Chenodeoxycholic acid (CDCA) induced [Ca²⁺]_i responses of individual cells corresponding to numbered ROIs in (B) (1–6). (C) Concurrent transmitted light image. (D) Dashed vertical line indicates the start of exposure to 1 mM CDCA. (E,F) Bee swarm plots with interquartile ranges and medians for delays of responses after stimulation with 1 mM CDCA (n = 65 cells from 4 slices) (E) and durations of transient [Ca²⁺]_i events (n = 38 cells from 4 slices) (F).