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. 2019 Jul 30;11:1759091419865788. doi: 10.1177/1759091419865788

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — HHcy diet causes early and progressive reductions in cerebral blood flow. Animals underwent pCASL for measurement of CBF after 6 and 10 weeks on HHcy diet. (a) Representative heat map of blood flow data from a coronal section. (b) Mice on HHcy diet had significantly reduced blood flow compared with controls at both 6 and 10 weeks. (c) Within-animal comparisons showed that CBF across time in the HHcy group was significantly reduced with increasing time on diet. Two animals included in the HHcy group in panel (b) were too sick to scan at 10 weeks and excluded from the analysis in panel (c). *p < .05, **p < .01 versus corresponding control or group indicated by connecting line, results of two-way ANOVA, n = 10–12 per group.

HHcy = hyperhomocysteinemia; CBF = cerebral blood flow.