Table 3.
Results of top ACPC-associated DMRs separated into those where there was a SNP influencing methylation levels nearby (gDMRs) and those where a nearby associated SNP (ngDMRs) was not found
| #chr | Start | End | #DMC | q values, mean | Methdiff, mean | Distance to TSS | Gene name |
|---|---|---|---|---|---|---|---|
| gDMRs | |||||||
| chr10 | 43140840 | 43140878 | 4 | 4.68E−06 | 12 | − 6574 | ZNF33B |
| chr13 | 114579169 | 114579173 | 4 | 6.20E−06 | 15 | 7288 | LINC00454 |
| chr19 | 13874993 | 13875015 | 4 | 5.42E−05 | − 12 | − 324 | MRI1 |
| chr4 | 185189026 | 185189056 | 4 | 0.000174 | 24 | − 49,927 | ENPP6 |
| chr12 | 42539166 | 42539215 | 8 | 6.22E−04 | 11 | − 518 | GXYLT1 |
| chr12 | 124858272 | 124858284 | 4 | 1.03E−03 | − 11 | − 36,490 | MIR6880 |
| chr12 | 11699957 | 11700234 | 22 | 0.00154 | − 14 | − 868 | LINC01252 |
| chr6 | 26755655 | 26755778 | 6 | 1.98E−03 | 12 | − 95,737 | ZNF322 |
| chr5 | 171203344 | 171203485 | 14 | 2.31E−03 | 11 | − 9461 | SMIM23 |
| chr15 | 91474603 | 91474621 | 4 | 0.00294 | − 10 | 1187 | HDDC3 |
| ngDMRs | |||||||
| chr13 | 114579169 | 114579173 | 4 | 6.20E−06 | 15 | 7288 | LINC00454 |
| chr14 | 24944437 | 24944579 | 10 | 8.84E−05 | − 12 | 32,349 | LOC101927045 |
| chr2 | 1370435 | 1370661 | 24 | 4.05E−04 | 11 | − 46,685 | TPO |
| chr12 | 42539166 | 42539215 | 8 | 6.22E−04 | 11 | − 518 | GXYLT1 |
| chr20 | 29523738 | 29524187 | 27 | 1.42E−03 | − 14 | 46,400 | LINC01598 |
| chr2 | 91850066 | 91850070 | 4 | 1.71E−03 | − 16 | − 2093 | LOC654342 |
| chr6 | 26755655 | 26755778 | 6 | 1.98E−03 | 12 | − 95,737 | ZNF322 |
| chr7 | 93996387 | 93996403 | 6 | 2.69E−03 | − 11 | − 27,478 | COL1A2 |
| chr15 | 91474603 | 91474621 | 4 | 0.00294 | − 10 | 1187 | HDDC3 |
| chr14 | 106865983 | 106866072 | 4 | 3.05E−03 | − 10 | − 72,417 | LINC00221 |