Table 2.

Model parameters for base case scenario and ranges used in uncertainty and sensitivity analyses.

Model input	Values	Range	Reference
Burden
Population estimates	Varies by country	–	[17]
Diarrheal mortality for children under 5 years of age	Varies by country	±10%; Triangular	[1], [22], [25]
Change in non-rotavirus under-5 diarrheal mortality rate	Varies by country; mean = 12.8% decline	±25%; Triangular	[23]
Diarrheal episodes in children under 5 years of age	Varies by region; 2.2–3.3 episodes/child annually	–	[6], [56]
Etiological fraction attributed to ETEC by WHO region	Varies by WHO region; 0.075–0.123	±25%; Triangular	[20], [24]
Etiological fraction attributed to Shigella by WHO region	Varies by WHO region; 0.002–0.238	±25%; Triangular	[20], [24]
Stunting induced by ETEC episodes	0.068 shift in HAZ	±50%; Triangular	[3], [6]
Stunting induced by Shigella episodes	0.082 shift in HAZ	±50%; Triangular	[3], [6]
Fraction of diarrhoeal episodes that are moderate to severe	22% of children who sought care at a healthcare facility	0.12–0.32; Triangular	[3], [6]
Percentage of caretakers that sought care at a health facility after a child’s diarrheal episode	47%	44–58%, Not varied in uncertainty analysis	[24]
Vaccination and Medical Costs
ETEC vaccine efficacy	60%	±20%; Triangular	Assumption
Shigella vaccine efficacy	60%	±20%; Triangular	Assumption
Dose price	$3.30	$2.50–$7.00; Triangular	Assumption
Administration cost	LI = $1.93, LMI = $1.64	±40%; Triangular	[48]
Cost of ETEC or Shigella illness	Varies by country; outpatient mean = $6.09/episode; inpatient mean = $51.07/episode	±40%; Triangular	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
Inpatient visit rate	12.5% of outpatient visits	±50%; Triangular	[30]
Outpatient visit rate (cases taken to healthcare facility)	Varies by country; Mean of 47% ETEC or Shigella cases sought treatment annually	44–58%, Not varied in uncertainty analysis	[24]