Table 1.
Oxygen equilibrium data for RBCs treated with antisickling agents.
| Antisickling agent (2 Mm) | AA cells (25% Hct) P50 (mmHg) |
AA cells ΔP50 (mmHg) |
AA cells Hill coefficient (n) | SS cells (25% Hct) P50 (mmHg) |
SS cells ΔP50 (mmHg) |
SS cells Hill coefficient (n) |
|---|---|---|---|---|---|---|
| Control (0) | 28.4 ± 0.19 | – | 2.81 ± 0.07 | 34.2 ± 0.71 | – | 2.86 ± 0.02 |
| TD-3 | 9.8 ± 0.30 | 18.6 | 1.66 ± 0.01 | 9.6 ± 0.40 | 24.6 | 1.67 ± 0.03 |
| 5HMF | 8.7 ± 0.21 | 19.7 | 1.25 ± 0.04 | 10.8 ± 1.26 | 24.1 | 1.39 ± 0.05 |
| HU | 28.1 ± 0.02 | 0.3 | 2.86 ± 0.03 | 33.97 ± 0.57 | 0.23 | 2.86 ± 0.04 |
| Gln | 28.1 ± 0.08 | 0.3 | 2.84 ± 0.04 | 33.73 ± 0.47 | 0.47 | 2.86 ± 0.04 |