Table 2.
SulfHb produced by the reaction of hydrogen peroxide (μM) with sickle Hb in the presence and absence of antisickling agent.
| H2O2/Hb | HbS | HbS-TD-3 (% Reduction) | HbS-5HMF | HbS-HU (% Reduction) | HbS-Gln |
|---|---|---|---|---|---|
| 0.5 | 12.7 ± 0.55 | 8.7 ± 0.95 (31.5%) | 13.2 ± 1.45 | 8.0 ± 1.41 (37.0%) | 12.5 ± 0.51 |
| 1 | 23.9 ± 0.45 | 12.5 ± 0.96 (47.7%) | 24.2 ± 1.82 | 10.4 ± 1.05 (56.5%) | 25.3 ± 0.85 |
| 2.5 | 28.1 ± 0.45 | 21.9 ± 1.74 (22.1%) | 29.5 ± 2.50 | 17.5 ± 1.42 (37.7%) | 27.3 ± 0.80 |
| 5 | 38.9 ± 0.44 | 26.1 ± 1.45 (32.9%) | 36.4 ± 2.15 | 23.9 ± 1.22 (38.6%) | 39.0 ± 0.92 |