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Summary of antisickling and antioxidant effects of agents under oxidative stress [2.5 H2O2/Hb (Heme)].
| Agents | O2 affinity | Autoxidation rate | Ferryl formation (% Reduction) | Delay time (s) | Cys93 modification |
|---|---|---|---|---|---|
| TD-3 | Increased | No effect | Reduced (22%) | 315 | ++ |
| 5-HMF | Increased | No effect | No effect | 158 | -- |
| HU | Increased | No effect | Reduced (38%) | 170 | ++ |
| L-Glutamine | No Effect | No effect | No effect | 158 | -- |
Modified = ++; not modified = --.
