Figure 7.

Survival curve. Shown is percent survival following infection with 2 × 10⁵ pfu of either 17LpLz/VP16p² or 17LpLz/VP16p²-R in male Swiss Webster mice. Survival of mice infected with HSV-1 strain McKrae is shown for comparison, emphasizing that the modest increase in virulence of VP16p² is well below the virulence of this naturally occurring HSV-1 strain. Data shown are compiled from two independent experiments n = 10 mice per group infected with either 17LpLz/VP16p² or 17LpLz/VP16p²-R (p = 0.039 Log-rank Mantel-Cox test). HSV-1 strain McKrae was evaluated at the same inoculation titer in a single experiment of four mice. *p ≤ 0.05.