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. Author manuscript; available in PMC: 2019 Aug 23.
Published in final edited form as: J Med Chem. 2018 Aug 10;61(16):7358–7373. doi: 10.1021/acs.jmedchem.8b01007

Figure 1.

Figure 1.

Homology models of LAT1 in outward-occluded (blue) and outward-open conformations (beige). (a) The superposed models are shown in a plane perpendicular to the membrane. (b) The models are shown through a “clipped plane” perpendicular to the membrane to visualize the gate, defined by Phe252 on TM6 (pink sticks). Docking pose of phenylalanine (cyan) in the (c) occluded model and (d) open conformation. The surface of the binding site is shown in transparence, highlighting the subpockets PA and PB.