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. Author manuscript; available in PMC: 2019 Aug 23.
Published in final edited form as: J Med Chem. 2018 Aug 10;61(16):7358–7373. doi: 10.1021/acs.jmedchem.8b01007

Figure 2.

Figure 2.

Scatter plots of IC50 values of meta-substituted L-phenylalanine analogues (Table 1) vs cLogP (a) and tPSA (b), indicating poor correlation between ligand polarity and potency. Calculated properties were obtained using ChemDraw v.16.