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. Author manuscript; available in PMC: 2019 Aug 23.
Published in final edited form as: J Med Chem. 2018 Aug 10;61(16):7358–7373. doi: 10.1021/acs.jmedchem.8b01007

Scheme 2.

Scheme 2.

Synthesis of Compounds 94 and 94-D (Started with D-Phe)a

aReagents and conditions: (a) PhCH(OMe)2, BF3-OEt2, Et2O, –78° to rt, 4 d, 44%, crystallization to give >95% single diastereomer; (b) KHMDS, isobutyl triflate, THF, –78° to rt, 18 h, 72%, flash chromatography; (c) KOSiMe3, THF, 75 °C, 3 h, 55%, preparative HPLC.