Table 2.
Effect of AT1 receptor blockade on AT2 receptor expression
| Stress | Tissue | AT2 mRNA | AT2 binding | References |
|---|---|---|---|---|
| Isolation stress (rats) | Brain (locus coeruleus, inferior olive) | = prevents stress-induced ↓ | Saavedra et al. (2006) | |
| Stress-sensitive rat strain (SHR) | Brain (locus coeruleus, inferior olive) | ↑ | Seltzer et al. (2004) | |
| Control rats | Brain (inferior olive) | = | Zhuo et al. (1994) | |
| Isolation stress (rats) | Adrenal gland (zona glomerulosa) | ↑ | ↑ | Armando et al. (2001) |
| Isolation stress (rats) | Adrenal gland (adrenal medulla) | ↑ | ↓ | Armando et al. (2001, 2004), Jezova et al. (2003) |
| Acute inflammation (LPS parenteral injection) (rats) | Adrenal gland (zona glomerulosa) | = | ↓ | Sanchez-Lemus et al. (2008) |
| Acute inflammation (LPS parenteral injection) (rats) | Adrenal gland (adrenal medulla) | = | ↓ | Sanchez-Lemus et al. (2008) |
| Stress-sensitive rat strain (SHR) | Adrenal gland (zona glomerulosa) | ↑ | Seltzer et al. (2004) | |
| Stress-sensitive rat strain (SHR) | Adrenal gland (adrenal medulla) | ↓ | Seltzer et al. (2004) | |
| Salt-restricted, nephrectomized (rats) | Adrenal gland (zona glomerulosa) | ↑ | Gigante et al. (1997) | |
| Control rats | Adrenal gland (zona glomerulosa) | ↓ | Zhuo et al. (1994) | |
| Control rats | Adrenal gland (adrenal medulla) | ↓ | Zhuo et al. (1994) | |
| Stress-sensitive rat strain (SHR) | Thoracic Aorta | ↑ | Cosentino et al. (2005) |
↑ increased, ↓ decreased, = no statistically significant change, empty squares: measurements not performed