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. 2019 Jun 11;9(8):1392–1402. doi: 10.1002/2211-5463.12676

Figure 4.

Figure 4

MALAT1 directly binds to YAP, enhances YAP expression and increases YAP transcriptional activity. (A) The luciferase activity of 8xGTIIC‐luciferase plasmid was determined in ESCC cells with or without MALAT1 knockdown. (B,C) The expression of connective tissue growth factor (CTGF), a target of YAP, was examined in the cells depicted in (A). (D) The protein level of YAP was detected in the cells described in (A). (E) The MALAT1 level pulled down by anti‐YAP was measured in ESCC cells. (F) YAP mRNA level was examined in the cells depicted in (A). (G) The promoter activity of YAP was determined in the cells described in (A). The difference was assayed using one‐way ANOVA with the Tukey–Kramer post hoc test. Data are presented as the mean ± SD, n ≥ 3, **P < 0.01 vs. Control or IgG.