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. 2019 Jul 31;9:11108. doi: 10.1038/s41598-019-47455-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue distribution of EV71 in orally infected NOD/SCID mice. Experimental design was as described in Fig. 1B. Paraffin-embedded sections of different tissues from moribund mice were visualized with immunohistochemistry using a rabbit antibody specific for EV71 protein VP1. (A) A summary of EV71 tissue tropism in this oral infection model. * incidence rates represent the numbers of VP1-positive organs divided by the total number of examined moribund mice. Strong signals of VP1 can be detected in (B) cardiomyocytes, (C) alveoli (black arrow) and epithelial-like cells (white arrow) in the lung, (D) morphologically characteristic Kupffer cells around the central vein, (E) myocytes of muscle. Centralized nuclei (black arrow) is known to be associated with muscle regeneration, (F) kidney glomerulus.