Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 31;9:11108. doi: 10.1038/s41598-019-47455-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Dissection of virus-host interactions in different tissues in the NOD/SCID mice infected with cloned EV71-F6. (A,B) A time course study on the expression profiles of inflammatory cytokines in the cardiopulmonary system by ELISA and RT-qPCR. Experimental design is as outlined in Fig. 1B. Sequential expression of IL6, IFN-γ, and IL-1β were detected in both heart and lung before, during, and after disease onset, respectively. In the ELISA data, dashed lines represent the cutoff value of minimal detectable dose. In the RT-qPCR data, dashed lines represent RNA expression levels relative to the saline control from an averaged value of at least 4 mice, with duplicated samples from each mouse. (C) A hypothesis of viral spreading from the oral-gut axis to peripheral tissues via blood circulation at earlier time points post-infection (data from Figs 1, 2, 6). Note: At the moribund stage, no virus was detected in the intestine (Fig. 2A).