Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of VAFs in PBMCs of Patient 1 between the bulk sequencing data and the aggregated single-cell sequencing data. The genes detected in both the bulk and the single-cell sequencing are bolded.
| Mutation | Function | Bulk | Single-cell | Bulk | Single-cell | Bulk | Single-cell |
|---|---|---|---|---|---|---|---|
| Clinical Status | Pre-BMT | Pre-BMT | Post-BMT | Post-BMT | Relapsed-AML | Relapsed-AML | |
| TP53 (c.379 T > A) | Missense | 9.83% | 8.94% | 46.30% | 42.08% | 76.60% | 65.82% |
| DNMT3A (c.2099 C > T) | Missense | 6.20% | N/A | 23.30% | N/A | 41.00% | N/A |
