Table 4.
DAVID pathway analysis of the top-5 pathways and related genes, deregulated after Cur-SLN treatment in MCF7 BC cell line.
| Pathway analysis of GEP induced by SLNB-Cur in MCF7 BC cell line | |||||
|---|---|---|---|---|---|
| Term | Genes count | % | P value | Genes | |
| 1 | Cytokine-cytokine receptor interaction | 21 | 0.0145 | 0.0257 | TNFRSF6B, TNF, OSMR, TNFRSF25, CSF1, LIFR, CD70, CX3CL1, CCL28, IL11RA, TGFB2, LIF, AMH, IL17A, IL20RB, CCR3, IL2RG, LTB, LTA, IL3RA, BMPR1A |
| 2 | Apoptosis | 9 | 0.0062 | 0.0186 | TNF, BAX, PIK3CD, CASP8, TP53, IL3RA, PIK3R1, AKT2, PIK3R2 |
| 3 | Platelet activation | 14 | 0.0097 | 0.0246 | F2RL3, ADCY2, PIK3CD, ITGA2, APBB1IP, COL5A2, JMJD7-PLA2G4B, P2RX1, PRKACA, COL1A1, COL11A2, PIK3R1, PIK3R2, AKT2 |
| 4 | Tyrosine metabolism | 6 | 0.0041 | 0.0397 | TYR, PNMT, MAOA, AOX1, HPD, AOC3 |
| 5 | Glucagon signaling pathway | 11 | 0.0076 | 0.0428 | LDHB, CPT1B, ADCY2, PYGM, GCK, PPP3R1, PRKACA, ACACB, PPARGC1A, GCGR, AKT2 |