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. 2019 Jul 31;9:11092. doi: 10.1038/s41598-019-47275-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The malCEST map of a rat brain tumor. (a) Anatomical T2-weighted image from axial slice showing the location of tumor as hyper intense region in the rat brain. (b) The T1-weighted image post Gd-DTPA administration highlights the tumor areas in the brain. (c–g) malCEST map from rat brain tumor shows increased contrast in tumor region following intravenous injection of maltitol peaking at 40 minutes following the start of injection (c, Pre-injection; d, 10 min; e, 40 min; f, 70 min; and g, 100 minutes post the beginning of maltitol administration).