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. 2019 Jul 31;9:11126. doi: 10.1038/s41598-019-47645-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Decision tree for the preventive therapy strategy. Individuals who screen positive on COR/IGRA are evaluated for active TB. Individuals found to have active TB are treated for disease, those found not to have active TB are provided 3HP. 3HP prevents progression to disease with a probability given by the adherence (Adh_3HP) and efficacy (Eff_3HP). SP_COR = specificity of COR; SE_I,COR = sensitivity of COR for progression to TB; SE_P,COR = sensitivity of COR for prevalent active TB; SP_L,IGRA = specificity of IGRA for M.tb infection; SE_L,IGRA = sensitivity of IGRA for M.tb infection; SE_I,IGRA = sensitivity of IGRA for progression to TB; SE_P,IGRA = sensitivity of IGRA for prevalent active TB; SP_D = specificity of evaluation for active TB; SE_D = sensitivity of evaluation for active TB; FP = false positive; TP = true positive; FN = false negative; TN = true negative. Full details of parameter values are given in Table 1.