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. 2019 Jul 31;9:11126. doi: 10.1038/s41598-019-47645-z

Table 1.

Parameters used to estimate outputs from a single round of screening.

Parameter Description Value
(mean and 95% CI)
Source
SEP,COR Sensitivity of COR for prevalent TB

0.91

(0.78–0.97)

Darboe et al.10
SEP,IGRA Sensitivity of IGRA for prevalent TB

0.84

(0.78–0.91)

Metcalfe et al.30
SEI,COR Sensitivity of COR for progression

0.71

(0.57–0.82)

Zak et al.9, Penn-Nicholson et al.31, Fiore-Gartland et al.11
SEI,IGRA Sensitivity of IGRA for progression

0.72

(0.58–0.82)

Rangaka et al.32
SPCOR Specificity of COR for progression*

0.84

(0.79–0.88)

Penn-Nicholson et al.31, Fiore-Gartland et al.11
SEL,IGRA Sensitivity of IGRA for M.tb infection

0.78

(0.73–0.82)

Pai et al.33
SPL,IGRA Specificity of IGRA for M.tb infection

0.96

(0.94–0.98)

Pai et al.33
SED Sensitivity of diagnosis (Xpert)

0.89

(0.81–0.94)

Steingart et al.34
SPD Specificity of diagnosis (Xpert)

0.99

(0.96–1)

Steingart et al.34
Adh3HP Proportion of those starting 3HP who complete (used in NNT calculation) 0.82 (0.61–0.95) Sterling et al.4, Sandgren et al.35
Eff3HP Efficacy of 3HP for preventing progression to TB in those who complete (used in NNT calculation) 0.6 (0.48–0.7) Smieja et al.3. Assumes that 3HP is non-inferior to isoniazid4.
L Proportion of population M.tb infected

0.5

(0.2–0.8)

Assumption
I Proportion of population who will progress to TB (incidence)

0.0046

(0.0028–0.0064)

Calculated for HIV-uninfected adults from WHO incidence estimates (see Appendix)
P Proportion of population with prevalent TB

0.0076

(0.0046–0.0106)

Calculated for HIV-uninfected adults from WHO incidence estimates (see Appendix)

Confidence intervals based on ACS/SHIP data were calculated using Wilson score interval. All parameters were assumed to follow beta distributions. Shape and scale parameters were estimated from median and 95% CI using the rriskdistributions package in R36. The susceptible population, S = 1 − LIP. *The specificity of COR is assumed to be independent of true infection status.