Table 1.
Top-ranked transcripts based on partial least-square discriminant analysis (PLS-DA) of Mn dose response (Top 30 transcripts, VIP ≥ 1.3).
| Mn dose effect | Gene name | Gene description (Homo sapiens) | VIP score | P-value | Literature |
|---|---|---|---|---|---|
| Up | GPR125 | Adhesion G protein–coupled receptor A3 | 1.60 | <0.0001 | Cell membrane signaling Brain injury (Pickering et al., 2008) |
| TAF5L | TAF5-like RNA polymerase II, p300/CBP-associated associated factor, 65kDa | 1.44 | 0.0025 | - | |
| TEX9 | Testis expressed 9 | 1.40 | 0.0051 | ||
| SLC12A7 | Solute carrier family 12 | 1.40 | 0.0007 | Potassium/chloride transporter (Karadsheh et al., 2004) | |
| OSGIN1 | Oxidative stress–induced growth inhibitor 1 | 1.40 | 0.0001 | Oxidative stress response (Brennan et al., 2017) | |
| ZZZ3 | Zinc finger, ZZ-type containing 3 | 1.38 | 0.0084 | Chromatin remodeling (Mi et al., 2018) | |
| ANKRD37 | Ankyrin repeat domain 37 | 1.34 | 0.0002 | − | |
| IARS | Isoleucyl-tRNA synthetase | 1.33 | 0.0201 | Amino acid metabolism; gene mutation associated with intellectual disability (Kopajtich et al., 2016) | |
| SNORD116-27 | Small nucleolar RNA, C/D box 116-27 | 1.31 | 0.0049 | − | |
| PARVA | Parvin, alpha | 1.30 | 0.0126 | Cytoskeletal remodeling (Olski et al., 2001) | |
| FUT4 | Fucosyltransferase 4 (alpha(1,3)fucosyltransferase, myeloid-specific) | 1.30 | 0.0030 | − | |
| Down | LINC00987 | Long intergenic non-protein-coding RNA 987 | 1.64 | 0.0001 | − |
| SKIDA1 | SKI/DACH domain containing 1 | 1.56 | <0.0001 | − | |
| PEAR1 | Platelet endothelial aggregation receptor 1 | 1.52 | 0.0073 | − | |
| TF | Transferrin | 1.51 | 0.0020 | Iron transport (Gkouvatsos et al., 2012) | |
| A1BG-AS1 | A1BG antisense RNA 1 | 1.47 | 0.0059 | ||
| DIRAS2 | DIRAS family, GTP-binding RAS-like 2 | 1.44 | 0.0023 | ADHD-associated gene (Reif et al., 2011; Grunewald et al., 2018) | |
| C21orf58 | Chromosome 21 open reading frame 58 | 1.43 | 0.0004 | − | |
| CHURC1-FNTB | CHURC1-FNTB readthrough | 1.40 | 0.0004 | − | |
| ASGR1 | Asialoglycoprotein receptor 1 | 1.38 | 0.0126 | − | |
| TERF2 | Telomeric repeat–binding factor 2 | 1.37 | 0.0041 | Protective activity of telomeres (Zhang et al., 2007) | |
| KRTAP5-AS1 | KRTAP5-1/KRTAP5-2 antisense RNA 1 | 1.35 | 0.0006 | − | |
| MYO15A | Myosin XVA | 1.35 | 0.0065 | Neurosensory function (Lloyd et al., 2001) | |
| TMEM105 | Transmembrane protein 105 (long noncoding RNA) | 1.35 | 0.0055 | − | |
| FAM154B | Stabilizer of axonemal microtubules 2 | 1.34 | 0.0125 | − | |
| ALPK3 | Alpha-kinase 3 | 1.34 | 0.0107 | − | |
| CAHM | Colon adenocarcinoma hypermethylated (non-protein coding) | 1.34 | 0.0018 | − | |
| OR1F1 | Olfactory receptor, family 1, subfamily F, member 1 | 1.33 | 0.0042 | Neurosensory function (Malnic et al., 2004) | |
| C2orf68 | Chromosome 2 open reading frame 68 | 1.32 | 0.0016 | − | |
| FRK | Fyn-related Src family tyrosine kinase | 1.30 | 0.0030 | Cell cycle, Parkinson’s associated gene (Anneren et al., 2003; Tan et al., 2018) |