Table 2.
The Enriched Gene Ontology Terms (top 10) and Kyoto Encyclopedia of Genes and Genomes of Target mRNAs.
| Category | Term | ID | FDR | Targeted mRNA |
|---|---|---|---|---|
| GO | Focal adhesion | GO: 0005925 | 0.015653541 | MYH9/ARHGAP31/ITGA3/CALR/GIT1/ARHGAP22/DLC1/GNA13/KLF11/EPHA2/STX16/ALCAM/YWHAE/ADD1/FGFR3 |
| GO | Cell-substrate adherens junction | GO: 0005924 | 0.015653541 | MYH9/ARHGAP31/ITGA3/CALR/GIT1/ARHGAP22/DLC1/GNA13/KLF11/EPHA2/STX16/ALCAM/YWHAE/ADD1/FGFR3 |
| GO | Cell-substrate junction | GO: 0030055 | 0.015653541 | MYH9/ARHGAP31/ITGA3/CALR/GIT1/ARHGAP22/DLC1/GNA13/KLF11/EPHA2/STX16/ALCAM/YWHAE/ADD1/FGFR3 |
| GO | Protein autophosphorylation | GO: 0046777 | 0.036590366 | AKT1/MINK1/FGFR1/MARK2/STK11/RAP2C/EPHA7/MAP3K9/TAOK1/EPHA4/FGFR3/MTOR |
| GO | Protein dephosphorylation | GO: 0006470 | 0.036590366 | CTDSP2/DUSP7/STK11/PTPRK/DLC1/UBASH3B/PTPRD/PPP1R15B/ARPP19/DUSP1/YWHAE/CTDSPL/MTMR3/MTOR |
| GO | Stress-activated MAPK cascade | GO: 0051403 | 0.036590366 | AKT1/MINK1/WNT7B/ZFP36L1/FOXM1/ZEB2/ZNF675/MAPKAPK2/MAP3K9/TAOK1/EPHA4/DUSP1/HMGB1 |
| GO | Regulation of binding | GO: 0051098 | 0.036590366 | AKT1/MARK2/CARM1/DISC1/UBASH3B/ZNF675/FOXC1/IGF1/EPHA4/SYAP1/PYGO2/RAPGEF2/HMGB1/STPG1/ADD1 |
| GO | Regulation of organ growth | GO: 0046620 | 0.036590366 | AKT1/FGFR1/CARM1/YAP1/FOXC1/IGF1/RBPJ/MTOR |
| GO | Ras protein signal transduction | GO: 0007265 | 0.037327922 | RAB11B/PLEKHG2/IQSEC3/ITGA3/NGFR/RAB7A/FOXM1/RAP2C/GRB2/OGT/DLC1/GNA13/RAB8B/RAB5B/IGF1/RAPGEF2 |
| GO | Positive regulation of organ growth | GO: 0046622 | 0.037327922 | AKT1/FGFR1/YAP1/IGF1/RBPJ/MTOR |
| KEGG | MAPK signaling pathway | hsa04010 | 0.000605175 | AKT1/MKNK2/FGFR1/NGFR/CACNB1/DUSP7/GRB2/EPHA2/MAPKAPK2/IGF1/TAOK1/FOS/DUSP1/RAPGEF2/FGFR3 |
| KEGG | Prostate cancer | hsa05215 | 0.018238418 | AKT1/FGFR1/GRB2/CCNE2/ZEB1/IGF1/MTOR |
| KEGG | Signaling pathways regulating pluripotency of stem cells | hsa04550 | 0.020225637 | AKT1/ZFHX3/FGFR1/WNT7B/GRB2/IGF1/SKIL/FGFR3 |
| KEGG | AMPK signaling pathway | hsa04152 | 0.033440098 | AKT1/RAB11B/STK11/SREBF1/SCD5/IGF1/MTOR |
| KEGG | Endocrine resistance | hsa01522 | 0.044793852 | AKT1/CARM1/GRB2/IGF1/FOS/MTOR |
| KEGG | PI3K-Akt signaling pathway | hsa04151 | 0.044793852 | AKT1/ITGA3/FGFR1/NGFR/STK11/GRB2/CCNE2/EPHA2/IGF1/YWHAE/FGFR3/MTOR |
GO – Gene Ontology, KEGG – Kyoto Encyclopedia of Genes; FDR – false discovery rate.