Table 4.
Chemical DUB inhibitors.
| DUB Inhibitors(DIs) | target | Cancer types | reference |
|---|---|---|---|
| HBX 41,108 | USP5, 7, 8 and UCH-L3 | myeloma | [50] |
| HBX -19,818 | USP7 | colon carcinoma | [51] |
| HBX-28,258 | USP7 | colon carcinoma | [51] |
| P5091 | USP7 | myeloma | [50] |
| P22077 | USP7 | - | [52] |
| GW7674 | USP1 | non-small cell lung cancer | [53, 54] |
| ML323 | USP1 and some DUBs | non-small cell lung cancer and osteosarcoma | [53, 54] |
| b-AP15 (VLX1500) |
UCHL5, USP14 and some DUBs | nonspecific | [55] |
| WPI 130 | USP5/USP9x/USP14/UCHL1/UCHL5 | breast cancer | [56, 57] |
| PR-619 | broad-range DUB inhibitor | - | [52] |