Figure 4. Osteocyte-specific deletion of Ctsk prevents bone loss in lactating mice.

Histomorphometric analysis of distal femurs from virgin and lactating Ctsk^fl/fl (black dots and squares, respectively) and Ctsk^ocy (red dots and squares, respectively) mice. Results represent the mean ± SEM. ^†P < 0.05 versus virgin Ctsk^fl/fl mice; ^‡P < 0.05 versus virgin Ctsk^ocy mice; and ^#P < 0.05 versus lactating Ctsk^fl/fl mice (n = 6–9 per group). A 2-way ANOVA followed by Fisher’s PLSD test was used to determine statistical significance. O.Th, osteoid thickness.