Figure 8. Inhibition of cardiolipin peroxidation reverts ABCA1 deficiency–mediated podocyte injury.

(A) Quantification of cytotoxicity normalized to viability in siABCA1 and siCO podocytes treated with NP and P sera and cotreated with E3, or not treated with E3 (n=5-16 pooled sera per group). (B) Albumin-to-creatinine ratios determined after 4 weeks of treatment in 16-week-old ob/+, ob/ob, Abca1^fl/fl ob/ob saline-treated (S) and Abca1^fl/fl ob/ob E3-treated mice (n = 5 per group). (C) Schematic representation of the current working model and major conclusions drawn from this study. One-way ANOVA followed by Tukey’s test. *P < 0.05;**P < 0.01; ***P < 0.001.